His first leading movie role was in the 2010 independent thriller Stolen.
He also had supporting roles in the movies The Town (2010), Sucker Punch (2011), and Bridesmaids (2011).
There, Hamm was arrested for participating with a violent hazing incident in November 1990.
Mark Sanders was beaten with a paddle and a broom by other fraternity members, while Hamm was leading him around the fraternity house, and Sanders' clothes were set afire.
In the series, set in a fictional 1960s advertising agency, he plays a suave, married advertising executive with an obscure past.
Alan Taylor and Mad Men creator Matthew Weiner initially thought Hamm was too handsome for the role but ultimately decided, "it was perfect to cast sort of the perfect male in this part".
He provided his voice to the animated movie Shrek Forever After during 2010, and during 2015, he featured in the animated movie Minions.